Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a coordinated attack on an underground arms cache in Syrian territory employed by the IS group, according to the UK's MoD.
The location, located using intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was positioned in mountainous terrain just to the north of Palmyra in the heart of Syria.
"Our fighter planes employed laser-guided Paveway IV weapons to target a number of access tunnels providing entry to the facility... preliminary assessments are that the objective was successfully hit," officials stated.
There was no sign of any civilian casualties in the strike on Saturday evening and each participating jet returned safely, the defence officials confirmed.
The British jets were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - also known as ISIS - imposed militant control over significant areas in Syria and Iraq prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and resolve to stand shoulder to shoulder with our partners, to eliminate any re-emergence of IS and their harmful and extremist ideologies in the region," UK Defence Secretary John Healey stated.
British military aircraft have carried out surveillance missions over Syria to "deter any efforts to regroup" of the group following its routing at the battle of Baghuz in the year 2019, the ministry said.
"I extend gratitude to all the members of British forces who took part in this mission for their expertise and their bravery," he said. "They were among a great many UK service members stationed over the holidays. This mission, to take out terrorist threats who threaten our way of life, shows how UK forces are ready to step up, all year round, protecting the UK within its borders and powerful internationally."
During December, the American forces conducted what it called a "major assault" targeting Daesh sites in Syria, after an ambush claimed the lives of two American soldiers and a civilian interpreter in Palmyra.
The United Nations reports IS still has roughly 5-7 thousand fighters in Syria and Iraq.
